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Compared with mouse thymocytes, mouse ES cells comprise increased ranges of whole genomic H3K4me3 and have larger H3K4me3 occupancy at the promoter of the pluripotent gene Oct4 forty six In settlement with this, international decreases in H3K4me3 levels occur throughout retinoic acid (RA)-induced differentiation of mouse ES cells 47 In addition, there are dynamic modifications in H3K4me3 profiles at particular sets of genes during ES cell differentiation.
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